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Peter Coates Lecture

In this series of lectures PKUK wishes to recognize the contributions and influence of the late Peter E Coates to the theory and practice of PKPD.

Although Peter spent his early years in San Francisco working with some of the giants of PKPD, it is for his distinguished career as a Clinical Pharmacology Leader in the Pharmaceutical Industry that he is most well-known (his industry affiliations included Napp, Beecham, Smith Kline Beecham, Pfizer and latterly GSK).

A few of his most cited publications are listed below:

Upton R., Sansom L., Guentert T., Powell R., Thiercelin J-F., Shah V., Coates P., Riegelman S. Evaluation of the absorption from 15 commercial theophylline products indicating deficiencies in currently applied bioavailability criteria, Journal of Pharmacokinetics and Biopharmaceutics (1980) 8: 229. doi:10.1007/BF01059644

M Ali, J W McDonald, J J Thiessen and P E Coates, Plasma acetylsalicylate and salicylate and platelet cyclooxygenase activity following plain and enteric-coated aspirin. Stroke. (1980) ;11:9-13

Holford, N., Coates, P., Guentert, T., Riegelman, S. and Sheiner, L. The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration-effect relationships.. British Journal of Clinical Pharmacology, (1981), 11: 187-195. doi:10.1111/j.1365-2125.1981.tb01123.x

Ballie S., Bateman D., Coates, P.E., and Woodhouse K. Age and the Pharmacokinetics of Morphine. Age Ageing (1989) doi: 10.1093/ageing/18.4.258

Brammer, K.W. & Coates, P.E., Pharmacokinetics of fluconazole in pediatric patients, Eur. J. Clin. Microbiol. Infect. Dis. (1994) 13: 325. doi:10.1007/BF01974613

With his passing in 2006 PKUK initiated this series of lectures where each year an invited speaker could in turn be recognised for their contributions to the theory and practice of PKPD.

PKUK would like to acknowledge and thank GSK for their continued support of the Peter Coates lecture.

2022 - Colin Pillai

Clinical Pharmacology in Africa - history, progress and lessons learnt for capacity strengthening programs

2020 and 2021 - Zoom meetings - no Peter Coates Lecture

2019 - Brian Houston

Underpredicting Clearance since 1994

2018 - Jeff Aronson

How modern medicine could have saved Charles II's life

2017 - France Mentre

20 years of optimal design in pharmacometrics: what for?

2016 - Jean-Louis Steimer (Novartis)

Pharmacometrics: Aged to perfection? View of a senior citizen

2015 - Lloyd Stevens (Early Clinical)

Nothing is certain except death, taxes and ........

2014 - Mats Karlsson (Uppsala University)

A Methodological Bias

2012 - Leon Aarons (University of Manchester)

Billy Connolly's World Tour of New Zealand 2006

2011 - Lawrence Lesko (US Food and Drug Administration)

Pharmacometric Solutions: A Question-Based Review 

2010 - Geoff Tucker (University of Sheffield/Simcyp)

The Virtual Patient: PBPK Applications in Drug Development

2009 - Malcolm Rowland (University of Manchester)

Mechanistic pharmacokinetics: Lighting a path to realisation

2008 - Dennis A. Smith (Pfizer)

Pushing the envelope: has PK/PD underperformed

2007 - Lloyd Sansom (University of South Australia)

From Science to Subsidy

2006 - Bob Powell (FDA)

A Reflection on Our Times and Trajectory